Patient Education
Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.
Topic Contents
Antibody Tests for Lupus
Overview
Antibody tests are a set of blood tests that check for specific antibodies to help clarify the diagnosis of lupus. They include:
- Anti-dsDNA (antibodies to DNA).
- Antinuclear antibody (ANA)
- Anti-RNP.
- Anti-Smith (Sm).
- Anti-SS-A (also called Ro).
- Anti-SS-B (also called La).
These antibody tests are often positive in lupus and can provide support for a diagnosis if the clinical criteria are unclear or if the ANA test is negative but lupus is strongly suspected.
- Anti-SS-A (Ro) and anti-SS-B (La) antibodies are not specific for lupus and are found commonly in Sjögren's syndrome. But these tests are useful in helping women with lupus who are considering pregnancy. If a woman who has these antibodies becomes pregnant, she may need more careful monitoring of the fetus, since these antibodies are associated with a higher risk of the baby being born with neonatal lupus syndrome or a heart defect called congenital heart block.
- High titers of anti-dsDNA are usually seen only in people who have lupus.
- A positive anti-Sm test is a specific marker for lupus.
Anti-dsDNA tests can be repeated at intervals to monitor how the disease is progressing.
Related Information
Credits
Current as of: July 10, 2023
Author: Healthwise Staff
Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
Current as of: July 10, 2023
Author: Healthwise Staff
Clinical Review Board
All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use and Privacy Policy. Learn how we develop our content.
To learn more about Healthwise, visit Healthwise.org.
© 1995-2024 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.